Non-genetic inheritance of environmental exposures: a protocol for a map of systematic reviews with bibliometric analysis
Direct effects of parental environment (particularly mothers) on offspring have been frequently demonstrated over the last decades. More recently ‘indirect’ non-genetic effects of ancestral environment and environmental effects through the patriline have been observed. Such research has captured the interest of many disciplines including biomedical science, toxicology, agriculture, and ecology and evolution due to the importance of understanding environmental effects on individual and population health. Consequently, the secondary literature, aimed at synthesizing non-genetic effects has also been increasing. The non-genetic inheritance secondary literature can be as diverse as the primary literature. Thus, there is a need to ‘map’ the non-genetic inheritance secondary literature to understand the state of the field and move forward in filling research gaps. Here, we ask four main questions: (1) What evidence exists on the impacts of non-genetic inheritance in non-human animals and plants across disciplines within the secondary ‘systematic-like’ (evidence synthesis) literature (2) What are the discipline-specific research patterns and gaps? (3) How connected is the literature (i.e., shared citations within and between disciplines, and collaborations between different countries)? (4) What is the overall quality of the non-genetic inheritance SR literature?
We systematically searched for published and grey evidence syntheses on non-genetic inheritance in non-human animals and plants. We then extracted details pertaining to research topics and assigned each article to one of five disciplines (agriculture, biomedical science, ecology and evolution, toxicology, and cross-disciplinary research). We mapped within- and between- discipline research patterns through descriptive statistics and visualizations, and conducted a bibliometric analysis of the ‘connectedness’ of the literature (i.e., co-citation and collaboration networks). We also conducted a critical appraisal of the included articles.
We have highlighted that certain areas of non-genetic inheritance are more frequently synthesised than others which may reflect a stronger interest in certain research topics at either the secondary or primary literature level. Presenting these research patterns and gaps in the literature that will not only make it easier to for researchers to understand the current state of the literature, but will also aid in bridging gaps between disciplines in the future. This will have substantial benefits for our understanding of non-genetic inheritance, with implications for many research fields, including climate change research, ecological and evolutionary theory, and understanding the effects of environmental pollutants on population health. It will also help policy makers identify relevant literature to inform policies, especially related to the negative impacts of environmental factors across generations.
Environmental effects, Scoping review, Inter-generational inheritance, Trans-generational inheritance, Maternal effects, Paternal effects